G-protein coupled receptor 109B; G-protein coupled receptor HM74; G-protein coupled receptor HM74B; niacin receptor 2; nicotinic acid receptor 2 (GPR109B, HM74B, NIACR2, HCAR3)

Function

• receptor for 3-OH-octanoid acid
• mediates negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in fatty acid beta-oxidation rates
• acts as a low affinity receptor for nicotinic acid
  • this effect requires pharmaceutical doses of nicotinic acid

Structure

• belongs to the G-protein coupled receptor 1 family

Compartment

• cell membrane; multi-pass membrane protein

Expression

• expression is largely restricted to adipose tissue & spleen

More general terms

• G-protein coupled receptor; serpentine receptor
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8843
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8843
• OMIM: https://mirror.omim.org/entry/606039
• UniProt: http://www.uniprot.org/uniprot/P49019.html