G-protein coupled receptor 39 (GPR39)

Function

• Zn+2 acts as a agonist
• mediates action by association with G proteins that activate a phosphatidylinositol-Ca+2 second messenger system
• effect is mediated mainly through Gq-alpha & G(12)/G(13) proteins
• involved in regulation of body weight, gastrointestinal motility, hormone secretion & cell death (putative)

Structure

• belongs to the G-protein coupled receptor 1 family

Compartment

• cell membrane; multi-pass membrane protein

Expression

• expressed in many tissues, including the stomach, intestine & hypothalamus

More general terms

• G-protein coupled receptor; serpentine receptor
• glycoprotein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2863
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2863
• OMIM: https://mirror.omim.org/entry/602886
• UniProt: http://www.uniprot.org/uniprot/O43194.html