G-protein coupled receptor 35; kynurenic acid receptor; KYNA receptor (GPR35)

Function

• receptor for kynurenic acid, an intermediate in tryptophan metabolism (kynurenine pathway)
• activity is mediated by G-proteins that elicit Ca+2 mobilization & inositol phosphate production through Gq proteins &/or Go proteins

Structure

• belongs to the G-protein coupled receptor 1 family

Compartment

• cell membrane; multi-pass membrane protein
• internalized to the cytoplasm after exposure to kynurenic acid

Expression

• predominantly expressed in immune system & gastrointestinal tissues

More general terms

• G-protein coupled receptor; serpentine receptor
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2859
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2859
• OMIM: https://mirror.omim.org/entry/602646
• UniProt: http://www.uniprot.org/uniprot/Q9HC97.html