G-protein coupled receptor 20 (GPR20)

Function

• orphan receptor with constitutive Gi signaling activity
• unclear if able to activate cyclic AMP pathway(s)

Structure

• belongs to the G-protein coupled receptor 1 family

Compartment

• cell membrane; multi-pass membrane protein

Expression

• ubiquitous
• highest levels in intestinal tissues
• expression in regions of the brain
  • detected in thalamus, putamen, & caudate,
  • not detected in frontal cortex, pons & hypothalamus

More general terms

• G-protein coupled receptor; serpentine receptor
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2843
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2843
• OMIM: https://mirror.omim.org/entry/601908
• UniProt: http://www.uniprot.org/uniprot/Q99678.html