G protein-coupled receptor 143 (ocular albinism type 1 protein, GPR143, OA1)

Function

• unknown
• binds heterotrimeric G proteins

Structure

belongs to the G-protein coupled receptor OA family

Compartment

• melanosome membrane

Expression

exclusively expressed in pigment cell

Pathology

• mutations in gene associated with:
  • ocular albinism with late-onset sensorineural deafness (OASD)
  • ocular albinism type 1

More general terms

• G-protein coupled receptor; serpentine receptor
• glycoprotein

Additional terms

• ocular albinism type 1 (OA1); Nettleship-Falls type ocular albinism
• ocular albinism with late-onset sensorineural deafness (OASD)

Database

• OMIM: https://mirror.omim.org/entry/300500
• OMIM: https://mirror.omim.org/entry/300650
• UniProt: http://www.uniprot.org/uniprot/P51810.html