proteinase-activated receptor 2; PAR-2; thrombin receptor-like 1; coagulation factor II receptor-like 1; G-protein coupled receptor 11 (F2RL1, GPR11, PAR2)
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Function
- receptor for trypsin & trypsin-like enzymes coupled to G proteins that stimulate phosphoinositide hydrolysis
- may have a role in the regulation of vascular tone
- proteolytic cleavage generates a new N-terminus that functions as a tethered ligand
Structure
belongs to the G-protein coupled receptor 1 family
Compartment
Expression
- widely expressed
- highly expressed in pancreas, liver, kidney, small intestine, & colon
- moderate expression is detected in many organs
- not expressed in brain or skeletal muscle
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P55085.html
- ↑ Wikipedia; protease-activated receptor entry http://en.wikipedia.org/wiki/protease-activated_receptor
- ↑ SeattleSNPs http://pga.gs.washington.edu/data/f2rl1/