solute carrier family 34 member 2 (SLC34A2, Na+ dependent phosphate transport protein 2B, Na+/phosphate cotransporter 2B, NaPi-2b, NaPi3b)

Function

• role in actively transporting phosphate into cells via Na+ cotransport (putative)
• may be the main phosphate transport protein in the intestinal brush border membrane
• role in synthesis of lung alveolar surfactant (putative)
• optimum pH=6.6

Structure

belongs to the SLC34A transporter family

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

• highly expressed in lung
• also detected in pancreas, kidney, small intestine, ovary, testis, prostate & mammary gland
• in lung, found in alveolar type II cells but not in bronchiolar epithelium
• down-regulated by EGF

Pathology

• defects in SLC34A2 are a cause of pulmonary alveolar microlithiasis

More general terms

• solute carrier family 34 (SLC34, SLC34A)
• transmembrane 8 protein
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1056
• OMIM: https://mirror.omim.org/entry/265100
• OMIM: https://mirror.omim.org/entry/604217
• UniProt: http://www.uniprot.org/uniprot/O95436.html