Na+/Cl- dependent GABA transporter 2; solute carrier family 6 member 13 (SLC6A13)
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Function
- Na+-dependent GABA & taurine transporter
- terminates action of GABA with high affinity
- Na+ dependent reuptake of GABA into presynaptic terminals
- may also be involved in beta-alanine transport
- KM=3.7 uM for GABA
- KM=20.2 uM for beta-alanine
Structure
Compartment
cell membrane; multi-pass membrane protein
Alternative splicing
named isoforms=3
Expression
- expressed in brain, kidney, lung, liver & testis
Genetics
- the SLC6A13 gene shows lineage-specific gene duplication in the human genome relative to chimpanzee & other great apes[2]
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q9NSD5.html
- ↑ 2.0 2.1 Fortna A, Kim Y, MacLaren E, Marshall K, Hahn G, Meltesen L, Brenton M, Hink R, Burgers S, Hernandez-Boussard T, Karimpour- Fard A, Glueck D, McGavran L, Berry R, Pollack J, Sikela JM. Lineage-specific gene duplication and loss in human and great ape evolution. PLoS Biol. 2004 Jul;2(7):E207. Epub 2004 Jul 13. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15252450
- ↑ PMID: https://www.ncbi.nlm.nih.gov/pubmed/22932902
- ↑ PMID: https://www.ncbi.nlm.nih.gov/pubmed/11824941
- ↑ PMID: https://www.ncbi.nlm.nih.gov/pubmed/17502375