vitamin K-dependent protein Z (PROZ)

Function

• appears to assist hemostasis by binding thrombin & promoting its association with phospholipid vesicles
• the iron & 2-oxoglutarate dependent 3-hydroxylation of aspartate & asparagine is (R) stereospecific within EGF domains

Structure

• belongs to the peptidase S1 family
• contains 2 EGF-like domains
• contains 1 Gla (gamma-carboxy-glutamate) domain
• contains 1 peptidase S1 domain

Compartment

secreted

Alternative splicing

named isoforms=2

Expression

plasma

Notes

• although homologous with vitamin K-dependent clotting factors, it has lost two of the essential catalytic residues & has no enzymatic activity

More general terms

• secreted peptide
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8858
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8858
• OMIM: https://mirror.omim.org/entry/176895
• UniProt: http://www.uniprot.org/uniprot/P22891.html