insulin-like growth factor-binding protein 6; IBP-6; IGF-binding protein 6; IGFBP-6 (IGFBP6 IBP6)

Function

• IGF-binding proteins prolong the half-life of the IGFs
• they either inhibit or stimulate the growth promoting effects of the IGFs on cell culture
• they alter the interaction of IGFs with their cell surface receptors

Structure

• O-glycosylated
  • O-linked glycans consist of hexose (probably gal), N-acetylhexosamine (probably galNAc) & sialic acid residues
  • O-glycosylated with core 1 glycan or possibly core 8 glycan
  • O-glycosylated on one site only in the region AA 143-168 in cerebrospinal fluid
• contains 1 IGFBP N-terminal domain
• contains 1 thyroglobulin type-1 domain

Compartment

secreted

More general terms

• insulin-like growth factor [IGF]-binding protein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3489
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3489
• OMIM: https://mirror.omim.org/entry/146735
• UniProt: http://www.uniprot.org/uniprot/P24592.html