N-acetylated-alpha-linked acidic dipeptidase 2; glutamate carboxypeptidase III; GCPIII; N-acetylated-alpha-linked acidic dipeptidase II; NAALADase II (NAALAD2)

Function

• N-acetylated-alpha-linked-acidic dipeptidase (NAALADase)
• dipeptidyl-peptidase IV type activity
• releases unsubstituted, C-terminal glutamyl residue, generally from Ac-Asp-Glu or folylpoly-gamma-glutamates
• inactivates the peptide neurotransmitter N-acetylaspartyl- glutamate

Inhibition: inhibited by quisqualate

Cofactor:

• binds 2 Zn+2 per subunit

Structure

• the NAALADase activity is found in the central region, the dipeptidyl peptidase IV type activity in the C-terminal
• belongs to the peptidase M28 family, M28B subfamily

Compartment

membrane

Expression

• testis > ovary, spleen > prostate, heart, placenta
• in brain, expressed in striatum, parietal cortex, ventral striatum > hippocampus, brain stem, putamen, superior colliculus

More general terms

• dipeptidase
• glycoprotein
• metalloprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10003
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10003
• OMIM: https://mirror.omim.org/entry/611636
• UniProt: http://www.uniprot.org/uniprot/Q9Y3Q0.html