hyaluronidase-3; hyal-3; hyaluronoglucosaminidase-3; lung carcinoma protein 3; LuCa-3 (HYAL3, LUCA3)

Function

• random hydrolysis of 1->4-linkages between N-acetyl-beta-D-glucosamine & D-glucuronate residues in hyaluronate tructure:
• belongs to the glycosyl hydrolase 56 family
• contains 1 EGF-like domain

Compartment

secreted, lysosome

Alternative splicing

named isoforms=5

Expression

expressed in bone marrow, testis, kidney

Pathology

• isoform 4 is detected in all bladder tumor & prostate tumor cells

More general terms

• hyaluronoglucosaminidase; hyaluronidase (HYAL)
• secreted protein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8372
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8372
• OMIM: https://mirror.omim.org/entry/604038
• UniProt: http://www.uniprot.org/uniprot/O43820.html