UDP-glucose:glycoprotein glucosyltransferase 2; UGT2; hUGT2; UDP-Glc:glycoprotein glucosyltransferase 2; UDP-glucose ceramide glucosyltransferase-like 2 (UGGT2, UGCGL2, UGT2)

Function

• recognizes glycoproteins with minor folding defects
• reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum
• reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum & refolding or degradation

Cofactor: Ca+2 or Mn+2

Structure

belongs to the glycosyltransferase 8 family

Compartment

• endoplasmic reticulum lumen
• endoplasmic reticulum-Golgi intermediate compartment

Expression

• expressed (at higher levels) in kidney, pancreas, heart, skeletal muscle

More general terms

• glucosyl transferase
• phosphoprotein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55757
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55757
• OMIM: https://mirror.omim.org/entry/605898
• UniProt: http://www.uniprot.org/uniprot/Q9NYU1.html