fucosyltransferase 9; alpha-(1,3)-fucosyltransferase; fucosyltransferase IX; fuc-TIX; fucT-IX; galactoside 3-L-fucosyltransferase (FUT9)

Function

• transfers fucose to lacto-N-neotetraose
  • but not to either
    • alpha2,3-sialyl lacto-N-neotetraose
    • lacto-N-tetraose.
• can catalyze last step in the biosynthesis of Lewis antigen,
• addition of a fucose to precursor polysaccharides
• protein glycosylation.

Structure

belongs to the glycosyltransferase 10 family

Compartment

• Golgi
• single-pass type 2 membrane protein (putative)

Expression

• expressed in forebrain, stomach > spleen, peripheral blood leukocytes
• No expression in small intestine, colon, liver, lung, kidney, adrenal cortex, uterus

More general terms

• fucosyltransferase
• glycoprotein
• membrane protein

Additional terms

• alpha-(1,3)-fucosyltransferase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10690
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10690
• OMIM: https://mirror.omim.org/entry/606865
• UniProt: http://www.uniprot.org/uniprot/Q9Y231.html