UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase; GlcNAc-1-P transferase; G1PT; GPT; N-acetylglucosamine-1-phosphate transferase (DPAGT1, DPAGT2)

Function

• catalyzes initial step in the synthesis of dolichol-pyrophosphate-oligosaccharides

protein modification; protein glycosylation

UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol

Structure

belongs to the glycosyltransferase 4 family

Compartment

• endoplasmic reticulum membrane
• multi-pass membrane protein

Alternative splicing

named isoforms=3

Pathology

• defects in DPAGT1 are the cause of congenital disorder of glycosylation type 1J

More general terms

• transmembrane 10e protein
• phosphotransferase
• glycoprotein

Additional terms

• congenital disorder of glycosylation type 1J
• dolichol phosphate
• UDP N-acetylglucosamine (UDP-GlcNAc)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1798
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1798
• OMIM: https://mirror.omim.org/entry/191350
• OMIM: https://mirror.omim.org/entry/608093
• UniProt: http://www.uniprot.org/uniprot/Q9H3H5.html