legumain; asparaginyl endopeptidase; protease, cysteine 1 (LGMN, PRSC1)

Function

• strict specificity for hydrolysis of asparaginyl bonds
• can also cleave aspartyl bonds slowly, especially under acidic conditions
• may be involved in the processing of proteins for MHC class 2 antigen presentation in the lysosomal/endosomal system
• hydrolysis of proteins & small molecule substrates at -Asn-|-Xaa- bonds

Structure

• glycosylated
• belongs to the peptidase C13 family

Compartment

lysosome (putative)

Expression

• ubiquitous
• particularly abundant in kidney, heart & placenta

More general terms

• protease; proteinase; endopeptidase
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5641
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5641
• OMIM: https://mirror.omim.org/entry/602620
• UniProt: http://www.uniprot.org/uniprot/Q99538.html