kallikrein-5 (stratum corneum tryptic enzyme, SCTE, kallikrein-like protein 2, KLK-L2)
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Function
- role in desquamation
Structure
- belongs to the peptidase S1 family, kallikrein subfamily
- contains 1 peptidase S1 domain
Compartment
Expression
Pathology
- overexpression of kallikrein-5 cleaves cathelicidin thus producing clinical manifestations of rosacea[3]
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q9Y337.html
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=25818
- ↑ 3.0 3.1 Yamasaki K, Di Nardo A, Bardan A, Murakami M, Ohtake T, Coda A, Dorschner RA, Bonnart C, Descargues P, Hovnanian A, Morhenn VB, Gallo RL. Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea. Nat Med. 2007 Aug;13(8):975-80. Epub 2007 Aug 5. PMID: https://www.ncbi.nlm.nih.gov/pubmed/17676051