semaphorin-3D (SEMA3D)

Function

• induces the collapse & paralysis of neuronal growth cones
• may act as repulsive cues toward specific neuronal populations
• binds to neuropilin (putative)

Structure

• strong binding to neuropilin is mediated by the C-terminal 3rd of the protein
• belongs to the semaphorin family
• contains 1 Ig-like C2-type domain (immunoglobulin-like)
• contains 1 PSI domain
• contains 1 sema domain

Compartment

• secreted (putative)

More general terms

• secreted protein
• glycoprotein
• semaphorin or semaphorin/collapsin family protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=223117
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:223117
• OMIM: https://mirror.omim.org/entry/609907
• UniProt: http://www.uniprot.org/uniprot/O95025.html