protein delta homolog 1; DLK-1; pG2; contains: fetal antigen 1; FA1 (DLK1, DLK)

Function

• may have a role in neuroendocrine differentiation
• precursor for fetal antigen 1 (same as pG2)

Structure

• N- & O-glycosylated
• monomer
• contains 6 EGF-like domains

Compartment

• membrane; single-pass type 1 membrane protein

Alternative splicing

• named isoforms=2; long, short
• additional isoforms seem to exist

Expression

• found within the stromal cells in close contact to the vascular structure of placental villi, yolk sac, fetal liver, adrenal cortex & pancreas & in the beta cells of the islets of Langerhans in the adult pancreas

Pathology

• expressed in neuroblastoma, pheochromocytoma & small cell lung carcinoma cell lines

Genetics

• preadipocyte factor 1 (PREF1) is also derived from the same gene as DLK & is expressed abundantly in preadipocytes

More general terms

• glycoprotein
• delta homolog protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8788
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8788
• OMIM: https://mirror.omim.org/entry/176290
• UniProt: http://www.uniprot.org/uniprot/P80370.html