lipid phosphate phosphohydrolase 2; phosphatidate phosphohydrolase 2c; PAP2-gamma; PAP2-G (PPAP2C, LPP2)

Function

• catalyzes the conversion of phosphatidic acid to diacylglycerol
• hydrolyzes lysophosphatidic acid, ceramide-1-phosphate & sphingosine-1-phosphate
• relative catalytic efficiency is phosphatidic acid > ceramide-1-phosphate > lysophosphatidic acid > sphingosine-1-phosphate
• inhibited by sphingosine, Zn+2 & propanolol

Structure

• homodimer (putative)
• belongs to the PA-phosphatase related phosphoesterase family

Compartment

membrane

Expression

found mainly in brain, pancreas & placenta

More general terms

• lipid phosphate phosphohydrolase; phosphatidate phosphohydrolase
• transmembrane 6 protein
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8612
• OMIM: https://mirror.omim.org/entry/607126
• UniProt: http://www.uniprot.org/uniprot/O43688.html