cytochrome b558 beta subunit (cytochrome b558 heavy chain, P22 phagocyte B-cytochrome, neutrophil cytochrome B 91 kD polypeptide, CGD91phox, gp91phox, heme binding membrane glycoprotein GP91PHOX, superoxide-generating NADPH oxidase heavy chain subunit, CYBB)
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Function
- component of the membrane-bound oxidase of phagocytes that generates superoxide
- terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior
- functions as a voltage-gated proton channel that mediates the H+ currents of resting phagocytes
- role in regulation of cellular pH & is blocked by Zn+2
Structure
- glycosylated
- contains 1 ferric oxidoreductase domain
Compartment
membrane
Pathology
- defects in CYBB are a cause of X-linked chronic granulomatous disease
More general terms
Additional terms
Component of
References
- ↑ Rotrosen D, Yeung CL, Leto TL, Malech HL, Kwong CH. Cytochrome b558: the flavin-binding component of the phagocyte NADPH oxidase. Science. 1992 Jun 5;256(5062):1459-62. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1318579
- ↑ Segal AW, Abo A. The biochemical basis of the NADPH oxidase of phagocytes. Trends Biochem Sci. 1993 Feb;18(2):43-7. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8488557
- ↑ Pawson T Protein modules and signalling networks Nature 373:573 1995 PMID: https://www.ncbi.nlm.nih.gov/pubmed/7531822
- ↑ CYBBbase; CYBB deficiency database http://bioinf.uta.fi/CYBBbase/
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=CYBB
- ↑ UniProt http://www.uniprot.org/uniprot/P04839.html