inhibin alpha chain (INHA)

Function

alpha chain of inhibin

Structure

• member of superfamily of proteins that includes TGF-beta, mullerian inhibitory factor, & activins

Compartment

secreted

Expression

• ovary - granulosa cells
• testis - Sertoli cells
• brain
• placenta
• adrenal cortex - zona reticularis & inner zona fasciculata

Pathology

• found in adrenocortical tumors
• expressed in prostate epithelium of
  • benign prostatic hyperplasia
  • basal cell hyperplasia & in nonmalignant regions of high grade prostate cancer

More general terms

• protein subunit
• glycoprotein
• TGF-beta family protein

More specific terms

• alpha inhibin-33
• alpha inhibin-91

Additional terms

• activin
• mullerian-inhibiting factor; anti-mullerian hormone; AMH; mullerian-inhibiting substance; MIS (AMH, MIF)
• transforming growth factor [TGF]-beta

Component of

• inhibin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3623
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3623
• OMIM: https://mirror.omim.org/entry/147380
• UniProt: http://www.uniprot.org/uniprot/P05111.html