periodic acid Schiff base (PAS)

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Introduction

Stains carbohydrates.

A tissue-stain in which 1,2-glycol groupings are 1st oxidized with periodic acid to aldehydes, which then react with sulfite leucofuschin reagent of Schiff & become colored red-violet.

Strong staining occurs with polysaccharides such as glycogen & mucopolysaccharides of epithelial mucins, basement membrane & connective tissue.

More general terms

Additional terms

References

  1. Stedman's Medical Dictionary 26th ed, Williams & Wilkins, Baltimore, 1995