carboxypeptidase-E (carboxypeptidase-H, prohormone-processing carboxypeptidase, enkephalin convertase, CPH, CPE)

Function

• removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing
• processes proinsulin

Cofactor: binds 1 Zn+2 per subunit (putative)

Structure

belongs to the peptidase M14 family

Compartment

• secreted
• secretory granules of pancreatic islets, adrenal gland, pituitary & brain

More general terms

• carboxypeptidase
• metalloprotein
• secreted protein
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P16870.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1363
• OMIM: https://mirror.omim.org/entry/114855
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1363