carboxypeptidase B2 (carboxypeptidase U, CPU, thrombin-activable fibrinolysis inhibitor, TAFI, plasma carboxypeptidase B, pCPB, CPB2)

Function

• cleaves C-terminal Arg or Lys from biologically active peptides including kinins or anaphylatoxins in the circulation thus regulating their activities

Cofactor: binds 1 Zn+2 per subunit (putative)

Structure

belongs to the peptidase M14 family

Compartment

secreted

Alternative splicing

named isoforms=2

Expression

plasma; synthesized in the liver

More general terms

• carboxypeptidase B
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1361
• OMIM: https://mirror.omim.org/entry/603101
• UniProt: http://www.uniprot.org/uniprot/Q96IY4.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1361