inter alpha antitrypsin heavy chain-3 (ITIH3, ITI heavy chain H3, inter-alpha-inhibitor heavy chain 3, serum-derived hyaluronan-associated protein, SHAP)

Function

• component of pre-alpha-inhibitor (P-alpha-I)
• carrier of hyaluronan in serum or binding protein between hyaluronate & other matrix protein(s)
• contains a potential peptide potentially stimulating phagocytotic cells

Structure

• belongs to the ITIH family
• contains 1 VWFA domain
• linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage (putative)

Compartment

secreted

Alternative splicing

named isoforms=2

More general terms

• inter alpha antitrypsin heavy chain
• glycoprotein

Component of

• pre-alpha-inhibitor (P-alpha-I)

Database

• OMIM: https://mirror.omim.org/entry/146650
• UniProt: http://www.uniprot.org/uniprot/Q06033.html