cardiomyopathy-associated protein 5 (myospryn, Dystrobrevin-binding protein 2, SPRY domain-containing protein 2, tripartite motif- containing protein 76, genethonin-3, CMYA5, C5orf10, DTNBP2, SPRYD2, TRIM76)

Function

• interacts with ACTN2, DTNBP1/dysbindin & PRKAR2A
• interacts with DES

Structure

• amphipathic helix regions act as an anchoring domain for PKA, & appear to be responsible of the interaction between myospryn & PRKAR2A
• contains 1 B30.2/SPRY domain
• contains 2 fibronectin F3 modules

Compartment

• cytoplasm (putative), perinuclear region (putative)
• found predominantly at the periphery of the nucleus but also throughout the cell
• localized at the Z-line costamere connection level of the sarcolemma & in lysosomes (putative)

Expression

• expressed in skeletal muscle; at a strong level & in heart

Pathology

• down-regulated in muscle cell lines derived from patients with Duchenne muscular dystrophy

More general terms

• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8N3K9.html