neurochondrin (NCDN KIAA0607)

Function

• probably involved in signal transduction in the nervous system
• required for the spatial learning process but not for differentiation or neurite outgrowth of neurons
• acts as a negative regulator of CaM kinase-2 phosphorylation
• may play a role in modulating melanin-concentrating hormone- mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction
• may be involved in bone metabolism
• overexpression in neural cell lines leads to stimulated neurite outgrowth; however, relevance in vivo unclear
• interacts with SEMA4C (putative)
• interacts with MCHR1

Structure

belongs to the neurochondrin family

Compartment

• cytoplasm, cell projection, dendrite
• ocalizes to somatic regions of neurons

Alternative splicing

named isoforms=3

Expression

• abundantly expressed in whole adult brain & in all individual brain regions examined, including spinal cord
• weakly expressed in ovary, testis, & fetal brain

More general terms

• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2315
• OMIM: https://mirror.omim.org/entry/608458
• UniProt: http://www.uniprot.org/uniprot/Q9UBB6.html