60 kD lysophospholipase [includes: L-asparaginase L-asparagine amidohydrolase; platelet-activating factor acetylhydrolase; PAF acetylhydrolase] (ASPG)

Function

• exhibits lysophospholipase, transacylase, PAF acetylhydrolase & asparaginase activities

2-lysophosphatidylcholine + H2O
                  <-->
glycerophosphocholine + a carboxylate

L-asparagine + H2O <--> L-aspartate + NH3

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O
                  <-->
1-alkyl-sn-glycero-3-phosphocholine + acetate

Structure

• monomer (putative)
• in the N-terminal section; belongs to the asparaginase
• contains 5 ANK repeats

Alternative splicing

named isoforms=2

More general terms

• lysophospholipase
• ankyrin repeat domain protein (ANKRD)
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3745
• UniProt: http://www.uniprot.org/uniprot/Q86U10.html