protein GRINL1A; glutamate receptor-like protein 1A (GRINL1A, POLR2M)

Function

• isoform 1 appears to be a stable component of pol-2G complex form of RNA polymerase 2
• isoform 1 may play a role in the mediator complex-dependent regulation of transcription activation
• isoform 1 acts in vitro as a negative regulator of transcriptional activation; this repression is relieved by the mediator complex, which restores pol-2G activator- dependent transcription to a level equivalent to that of pol-2
• isoform 1 is a component of the pol-2G complex

Structure

belongs to the GRINL1 family

Compartment

isoform 1: nucleus (probable)

Alternative splicing

named isoforms=6 Additional isoforms seem to exist

Expression

• detected in adult an fetal brain
• detected in heart, kidney, skeletal muscle, small intestine, lung, prostate & testis

Genetics

• the adjacent GCOM1 & GCNA1 genes are both part of a complex transcription unit, the respective transcripts derive from different promoters & are alterantively spliced
• in humans, some transcripts of the upstream promoter of GCOM1 splice use exons of the downstream GRINL1A gene

More general terms

• phosphoprotein

More specific terms

• protein GRINL1A, isoforms 15/16 (GRINL1A)

Component of

• RNA polymerase 2 core element pol II(G); pol-2G

Database

• OMIM: https://mirror.omim.org/entry/606485
• UniProt: http://www.uniprot.org/uniprot/P0CAP2.html