dynein heavy chain 1, axonemal (ciliary dynein heavy chain 1, axonemal beta dynein heavy chain 1, heat shock regulated protein 1, XLHSRF-1, hDHC7, DNAH1, DHC7, DNAHC1, KIAA1410)

Function

• dynein heavy chain
• force generating protein of respiratory cilia
• involved in sperm motility
• implicated in sperm
• flagellar assembly (putative)
• consists of at least two heavy chains & a number of intermediate & light chains

Structure

• belongs to the dynein heavy chain family
• contains 19 LRR repeats (leucine-rich repeats)

Compartment

cell projection, cilium axoneme (putative)

Alternative splicing

named isoforms=3

Expression

• expressed primarily in trachea & testis
• also expressed in brain

More general terms

• phosphoprotein
• dynein heavy chain

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2598
• OMIM: https://mirror.omim.org/entry/603332
• UniProt: http://www.uniprot.org/uniprot/Q9P2D7.html