nicotinate phosphoribosyltransferase (NAPRTase, nicotinate phosphoribosyltransferase domain-containing protein 1, FHA-HIT-interacting protein, NAPRT1, FHIP)

Function

• catalyzes the conversion of nicotinic acid to nicotinic acid mononucleotide
• essential for nicotinic acid to increase cellular NAD levels & prevent oxidative stress of the cells
• cofactor biosynthesis; NAD+ biosynthesis
• nicotinate ribonucleotide from nicotinate: step 1/1

nicotinate D-ribonucleotide + diphosphate <--> nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate

Structure

belongs to the NAPRTase family

Compartment

cytoplasm, cytosol

Alternative splicing

named isoforms=4

More general terms

• phosphoribosyltransferase
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q6XQN6.html