myotubularin-related protein 12 (phosphatidylinositol-3 phosphate 3-phosphatase adapter subunit, 3-phosphatase adapter protein, 3-PAP, MTMR12, KIAA1682, PIP3AP)

Function

• catalytically inactive phosphatase
• plays a role as an adapter for the phosphatase myotubularin to regulate myotubularin intracellular location
• interacts with myotubularin MTM1 & myotubularin-related MTMR2

Structure

• belongs to the protein-tyrosine phosphatase family non-receptor class myotubularin subfamily
• contains 1 myotubularin phosphatase domain
• lacks the phosphocysteine intermediate Cys active site in position 391 that is replaced by a Glu residue, preventing the hydrolase activity

Compartment

• cytoplasm
• localizes to punctate vesicles when associated with MTM1

Alternative splicing

named isoforms=3

Expression

• ubiquitous
• prominent expression in brain, heart, kidney, placenta, & lung

More general terms

• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/606501
• UniProt: http://www.uniprot.org/uniprot/Q9C0I1.html