inverted formin-2 (HBEBP2-binding protein C, INF2, C14orf151, C14orf173)

Function

• severs actin filaments & accelerates their polymerization & depolymerization (putative)
• interacts with actin at the FH2 domain (putative)
• phosphate inhibits both the depolymerization & severing activities

Structure

• WH2 domain acts as the DAD (diaphanous autoregulatory) domain & binds to actin monomers (putative)
• regulated by autoinhibition due to intramolecular GBD-DAD
• binding (putative)
• severing activity is dependent on covalent attachment of the FH2 domain to the C-terminus (putative)
• belongs to the formin homology family
• contains 1 FH2 (formin homology 2) domain
• contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain
• contains 1 WH2 domain

Alternative splicing

named isoforms=3

More general terms

• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q27J81.html