malignant fibrous histiocytoma amplified sequence 1 (malignant fibrous histiocytoma-amplified sequence with leucine-rich tandem repeats 1, MFHAS1, MASL1)

Structure

• contains 13 LRR repeats (leucine-rich repeats)

Expression

• ubiquitously expressed.

Pathology

• overexpressed in malignant fibrous histiocytomas
• chromosomal translocation t(8;14)(p23.1;q21) involving MFHAS1 with a cryptic exon named '14q21 element' may be a cause of B-cell lymphoma, resulting fusion protein named 'chimeric MASL1' is tumorigenic in nude mice

More general terms

• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/605352
• UniProt: http://www.uniprot.org/uniprot/Q9Y4C4.html