probable O-sialoglycoprotein endopeptidase 2 (O-sialoglycoprotein endopeptidase-like protein 1, OSGEPL1)

Function

• O-sialoglycoprotein endopeptidases specifically cleave the polypeptide backbone of membrane glycoproteins that contain clusters of O-linked sialoglycans (putative)
• hydrolysis of O-sialoglycoproteins; cleaves 31-Arg-|-Asp-32 bond in glycophorin A
• does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated

Cofactor: Zn+2 (probable)

Structure

belongs to the peptidase M22 family

Alternative splicing

named isoforms=3

More general terms

• phosphoprotein
• metalloprotease

Additional terms

• tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP; O-sialoglycoprotein endopeptidase; hOSGEP; t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEP (OSGEP, GCPL1)

Database

• UniProt: http://www.uniprot.org/uniprot/Q9H4B0.html