tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP; O-sialoglycoprotein endopeptidase; hOSGEP; t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEP (OSGEP, GCPL1)

Function

• required for formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (putative)
• apparently does not have endopeptidase activity

Structure

belongs to the KAE1 / YgjD family

Expression

• widely expressed at low level
• expressed in heart, placenta, liver, kidney, lung, brain, skeletal muscle & pancreas

More general terms

• metalloprotein

Additional terms

• probable O-sialoglycoprotein endopeptidase 2 (O-sialoglycoprotein endopeptidase-like protein 1, OSGEPL1)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55644
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55644
• OMIM: https://mirror.omim.org/entry/610107
• UniProt: http://www.uniprot.org/uniprot/Q9NPF4.html