ubiquitin carboxyl-terminal hydrolase 34 (ubiquitin thioesterase 34, ubiquitin-specific-processing protease 34, deubiquitinating enzyme 34, USP34, KIAA0570, KIAA0729)

Function

• recognizes & hydrolyzes peptide bond at C-terminal Gly of ubiquitin
• role in processing of poly-ubiquitin precursors & ubiquinated proteins
• phosphorylated upon DNA damage, probably by ATM or ATR

Ubiquitin C-terminal thioester + H2O <--> ubiquitin + a thiol

Structure

• belongs to the peptidase C19 family

Alternative splicing

named isoforms=2

Expression

• expressed in brain at low level

More general terms

• ubiquitin C-terminal hydrolase
• phosphoprotein

Additional terms

• ubiquitin (UBCEP2, UBB, UBC)

Database

• UniProt: http://www.uniprot.org/uniprot/Q70CQ2.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9736