PAB-dependent poly(A)-specific ribonuclease subunit 2 (hPan2, inactive ubiquitin carboxyl-terminal hydrolase 52, USP52, KIAA0710, PAN2)

Function

• cytoplasmic mRNA decay
• component of Pan nuclease complex
• interacts with PAN3 to form the Pan nuclease complex

Structure

• belongs to the peptidase C19 family PAN2 subfamily
• contains 1 exonuclease domain
  • has no ubiquitin carboxyl terminal hydrolase activity since it lacks a conserved catalytic Cys at position 525

Compartment

• cytoplasm, nucleus
• shuttles between nucleus & cytoplasm

Alternative splicing

named isoforms=3

More general terms

• enzyme catalytic subunit
• phosphoprotein

Component of

• PAN nuclease complex

Database

• UniProt: http://www.uniprot.org/uniprot/Q504Q3.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9924