PAB-dependent poly(A)-specific ribonuclease subunit 3 (hPan3, PAN3)

Function

• cytoplasmic mRNA decay
• component of Pan nuclease complex
• recruits polyadenylate-binding protein which in turn stimulates PAN2 nuclease activity
• interacts with PAN2 to form the Pan nuclease complex
• mediates the interaction of the Pan nuclease complex with polyadenylate-binding protein

Structure

• belongs to the PAN3 family
• contains 1 protein kinase domain predicted to be catalytically inactive

Compartment

cytoplasm

Alternative splicing

named isoforms=3

More general terms

• enzyme regulatory subunit

Component of

• PAN nuclease complex

Database

• UniProt: http://www.uniprot.org/uniprot/Q58A45.html