peptidyl-prolyl cis-trans isomerase-like 4 (PPIase, Rotamase, cyclophilin-like protein PPIL4, PPIL4)

Function

• PPIases accelerate the folding of proteins
• catalyzes cis-trans isomerization of proline imidic peptide bonds in oligopeptides

Peptidylproline (omega=180) <--> peptidylproline (omega=0)

Structure

• belongs to the cyclophilin-type PPIase family, PPIL4 subfamily
• contains 1 PPIase cyclophilin-type domain
• contains 1 RRM domain (RNA recognition motif)

Compartment

nucleus

Expression

• abundantly expressed in kidney
• ubiquitously low expression pattern in other adult tissues

More general terms

• peptidyl-prolyl cis/trans isomerase (PPIase) or rotamase
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/607609
• UniProt: http://www.uniprot.org/uniprot/Q8WUA2.html