acetoacetyl-CoA synthetase (acyl-CoA synthetase family member 1, protein sur-5 homolog, AACS, ACSF1)

Function

• activates acetoacetate to acetoacetyl-CoA
• may be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (putative)

ATP + acetoacetate + CoA <--> AMP + diphosphate + acetoacetyl-CoA

Structure

• belongs to the ATP-dependent AMP-binding enzyme family

Compartment

cytoplasm, cytosol (putative)

Alternative splicing

named isoforms=3

Expression

• highly expressed in kidney, heart & brain
• low expression in liver

More general terms

• acyl coenzyme-A [CoA] synthetase or acyl coenzyme-A [CoA] ligase
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q86V21.html