molybdenum cofactor sulfurase (MoCo sulfurase, MOS, HMCS, MOCOS)

Function

• sulfurates molybdenum cofactor
• sulfation of molybdenum is essential for xanthine dehydrogenase & aldehyde oxidase in which molybdenum cofactor is liganded by 1 oxygen & 1 sulfur atom in active form

Cofactor: pyridoxal phosphate

Pathology

• defects in MOCOS are the cause of xanthinuria type 2

More general terms

• lyase
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/603592
• UniProt: http://www.uniprot.org/uniprot/Q96EN8.html