Caprin-2 (cytoplasmic activation/proliferation-associated protein 2, C1q domain-containing protein 1, EEG-1, gastric cancer multidrug resistance-associated protein, CAPRIN2, C1QDC1, EEG1, KIAA1873)
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Function
- role in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation
- overexpression is associated with increased apoptosis
Structure
contains 1 C1q domain
Compartment
- isoform 1: cytoplasm
- isoform 2: mitochondrion, cytoplasm, expressed throughout the cytoplasm
- isoform 5: mitochondrion colocalizes with aggregated mitochondria
Alternative splicing
named isoforms=9
Expression
- detected in all tissues tested
- highest levels of expression in brain & spleen
- expression is highly regulated during erythroid development with increased expression at the stage of differentiation associated with the onset of global nuclear condensation & diminished cell proliferation