Caprin-2 (cytoplasmic activation/proliferation-associated protein 2, C1q domain-containing protein 1, EEG-1, gastric cancer multidrug resistance-associated protein, CAPRIN2, C1QDC1, EEG1, KIAA1873)

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Function

  • role in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation
  • overexpression is associated with increased apoptosis

Structure

contains 1 C1q domain

Compartment

Alternative splicing

named isoforms=9

Expression

  • detected in all tissues tested
  • highest levels of expression in brain & spleen
  • expression is highly regulated during erythroid development with increased expression at the stage of differentiation associated with the onset of global nuclear condensation & diminished cell proliferation

More general terms

References

Database