nucleoporin NDC1 (hNDC1, transmembrane protein 48, TMEM48, NDC1)

Function

• component of the nuclear pore complex
• role in de novo assembly & insertion of nuclear pore complex in the nuclear envelope.
• required for nuclear pore complex & nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane & soluble nucleoporins, thus anchoring the nuclear pore complex in the membrane
• interacts with the NUP35/NUP53 (putative)
• phosphorylated

Structure

belongs to the NDC1 family

Compartment

• nucleus, nuclear pore complex, membrane
• central core structure of the nuclear pore complex

Alternative splicing

named isoforms=4

More general terms

• transmembrane 6 protein
• nuclear protein
• phosphoprotein

Component of

• nuclear pore complex (NPC)

Database

• UniProt: http://www.uniprot.org/uniprot/Q9BTX1.html