AMY-1-associating protein expressed in testis 1 (MAATS1, AAT-1, AAT1, C3orf15)

Function

• isoform 4 may play a role in spermatogenesis
• interacts with AMY1 & AKAP1
• isoform 4 belongs to a complex together with AMY1, AKAP1 & PRKAR2B
• isoform 3 does not interact with AMY1
• isoform 4 is phosphorylated by PKA

Compartment

• cytoplasm, mitochondrion
• isoform 4 is found in the mitochondria & localized in the neck of the sperm

Alternative splicing

• named isoforms=5
• additional isoforms (AAT-1L & AAT-1S) may exist
• alternative promoter usage

Expression

• isoform 1 is strongly expressed in liver
• isoform 4 is widely expressed, but strongly expressed in all spermatogenesis-related tissues, including the testis, epithelium of cauda & the corpus epididymis
• isoform 4 is present in the spermatid & mature sperm
• isoform 4 is also expressed in Leydig cells
• isoform 3 is expressed in testis

More general terms

• mitochondrial protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q7Z4T9.html