protein capicua homolog (CIC, KIAA0306)

Function

• transcriptional repressor which may play a role in development of the central nervous system (CNS)
• interact with ATXN1 (putative)

Structure

contains 1 HMG box DNA-binding domain

Compartment

nucleus (putative)

Expression

expressed in fetal brain

Pathology

expressed in medulloblastoma

More general terms

• transcriptional silencer (transcriptional repressor)
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q96RK0.html