protein furry homolog-like (ALL1-fused gene from chromosome 4p12, FRYL, AF4P12, KIAA0826)

Function

• role in maintaining integrity of polarized cell extensions during morphogenesis
• regulates actin cytoskeleton
• role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites
• limits dendritic branching
• transcriptional activator (putative)

Structure

belongs to the furry protein family

Alternative splicing

named isoforms=2

Expression

• widely expressed
• higher expression in colon, placenta, brain & cells of lymphoid origin

Pathology

• chromosomal translocation t(4;11)(p12;q23) involving FRYL with MLL is found in treatment-related acute lymphoblastic leukemia (ALL)
• forms a MLL-FRYL fusion protein

More general terms

• phosphoprotein

Additional terms

• protein furry homolog (FRY C13orf14)

Database

• UniProt: http://www.uniprot.org/uniprot/O94915.html