phospholipase C-like protein 2 (phospholipase C epsilon 2, phospholipase C-L2, PLC-L2, PLCL2, KIAA1092, PLCE2)

Function

• role in regulation of Ins(1,4,5)P3 (IP3) around the endoplasmic reticulum

Structure

• contains 1 C2 domain
• contains 1 PH domain
• contains 1 PI-PLC X-box domain, lacks essential His-486, replaced by Thr, thus inactive
• contains 1 PI-PLC Y-box domain

Compartment

• cytoplasm
• predominantly localized to perinuclear areas in both myoblast and myotube C2C12 cells

Alternative splicing

named isoforms=3

More general terms

• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9UPR0.html