polycomb protein SCMH1 (sex comb on midleg homolog 1, SCMH1)

Function

• component of the Polycomb group multiprotein PRC1 complex
• interacts with the SAM domain of PHC1 via its SAM domain in vitro

Structure

• belongs to the SCM family
• contains 2 MBT repeats
• contains 1 SAM domain (sterile alpha motif)

Compartment

nucleus

Alternative splicing

named isoforms=5

Expression

• strongly expressed in heart, muscle & pancreas
• weakly expressed in brain, placenta, lung, liver & kidney

More general terms

• protein subunit
• phosphoprotein

Component of

• Polycomb group multiprotein PRC1 complex (PcG PRC1 complex, hPRC-H, PcG repressive complex 1)

Database

• UniProt: http://www.uniprot.org/uniprot/Q96GD3.html